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Childhood vaccinations and risk of asthma

DESTEFANO, FRANK MD; GU, DAVID PhD; KRAMARZ, PIOTR MD; TRUMAN, BENEDICT I. MD; IADEMARCO, MICHAEL F. MD; MULLOOLY, JOHN P. PhD; JACKSON, LISA A. MD; DAVIS, ROBERT L. MD; BLACK, STEVEN B. MD; SHINEFIELD, HENRY R. MD; MARCY, S. MICHAEL MD; WARD, JOEL I. MD; CHEN, ROBERT T. MDTHE VACCINE SAFETY DATALINK RESEARCH GROUP

The Pediatric Infectious Disease Journal: June 2002 - Volume 21 - Issue 6 - p 498-504
Original Studies

Background. A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma.

Methods. Cohort study involving 167 240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings.

Results. In the study 18 407 children (11.0%) developed asthma, with a median age at onset of 11 months. The relative risks (95% confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (MMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine.

Conclusion. There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.

From the Centers for Disease Control and Prevention (FD, PK, BIT, MFI, RTC) and Emory University (DG), Atlanta, GA; the Center for Health Research, Northwest Kaiser Permanente, Portland, OR (JPM); the Center for Health Studies, Group Health Cooperative, Seattle, WA (LAJ, RLD); the Pediatric Vaccine Study Center, Northern California Kaiser Permanente, Oakland, CA (SBB, HRS); Kaiser Foundation Hospital, Panorama City, CA (SMM); and the Center for Vaccine Research, Harbor-UCLA Medical Center, Torrance, CA (JIW).

Accepted for publication Jan. 14, 2002.

Reprints not available.

© 2002 Lippincott Williams & Wilkins, Inc.