B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined with the detection of anti-B19 Immunoglobulin G (IgG), B19 DNA and B19 mRNA in liver indicate a persistent infection and suggest a diagnosis of parvovirus B19-associated acute liver failure.
From the *Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; and †Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, Brasil.
Accepted for publication July 2, 2017.
Disclosure: The authors report no actual or potential conflict of interest in relation to this article. This work was supported by grants from Instituto Oswaldo Cruz - FIOCRUZ and FAPERJ (Fundação de Amparo à Pesquisa no Estado do Rio de Janeiro) / RJ-Brasil.
Address for correspondence: Arthur Alves, MSc, Laboratório de Desenvolvimento Tecnológico em Virologia - IOC/Fiocruz, Rio de Janeiro, RJ. 20245–900, Brasil. E-mail: email@example.com.