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Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure

Leon, Luciane Almeida Amado PhD*; Alves, Arthur Daniel Rocha MSc*; Garcia, Rita de Cássia Nasser Cubel PhD; Melgaço, Juliana Gil PhD*; de Paula, Vanessa Salete PhD*; Pinto, Marcelo Alves PhD*

The Pediatric Infectious Disease Journal: December 2017 - Volume 36 - Issue 12 - p e355–e358
doi: 10.1097/INF.0000000000001731
Brief Reports

B19V has been proposed as an etiologic agent for hepatitis, mainly in children, but this is a rare clinical occurrence. In this article, we report a case of non-A-E acute liver failure in an immunocompetent child with B19 infection. The clinical findings of severe anemia and pancytopenia combined with the detection of anti-B19 Immunoglobulin G (IgG), B19 DNA and B19 mRNA in liver indicate a persistent infection and suggest a diagnosis of parvovirus B19-associated acute liver failure.

From the *Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil; and Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, Brasil.

Accepted for publication July 2, 2017.

Disclosure: The authors report no actual or potential conflict of interest in relation to this article. This work was supported by grants from Instituto Oswaldo Cruz - FIOCRUZ and FAPERJ (Fundação de Amparo à Pesquisa no Estado do Rio de Janeiro) / RJ-Brasil.

Address for correspondence: Arthur Alves, MSc, Laboratório de Desenvolvimento Tecnológico em Virologia - IOC/Fiocruz, Rio de Janeiro, RJ. 20245–900, Brasil. E-mail: arthur.alves@ioc.fiocruz.br.

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