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First Cases of Severe Flaccid Paralysis Associated With Enterovirus D68 Infection in Spain, 2015–2016

Cabrerizo, María PhD*; García-Iñiguez, Juan Pablo MD, PhD; Munell, Francina MD, PhD; Amado, Alfonso MD§; Madurga-Revilla, Paula MD; Rodrigo, Carlos MD, PhD‡¶; Pérez, Sonia PhD; Martínez-Sapiña, Ana MD**; Antón, Andrés PhD††; Suárez, Gerardo MD§; Rabella, Nuria MD, PhD‡‡; del Campo, Víctor MD§§; Otero, Almudena*; Masa-Calles, Josefa MD, PhD¶¶

The Pediatric Infectious Disease Journal: December 2017 - Volume 36 - Issue 12 - p 1214–1216
doi: 10.1097/INF.0000000000001668
Brief Reports

Enterovirus D68 was known to be the cause of mild to severe respiratory infections, but in the last few years, it has also been associated with myelitis and paralysis. This report describes the first Enterovirus D68 detections in acute flaccid paralysis cases occurring between December 2015 and March 2016 in Spain.

From the *Spanish National Poliovirus Laboratory, National Centre for Microbiology, Institute of Health “Carlos III”, Madrid, Spain; Department of Pediatrics and **Department of Microbiology, Miguel Servet Hospital, Zaragoza, Spain; Department of Pediatrics, Vall d’Hebron University Hospital and Autonoma University, Barcelona, Spain; §Department of Pediatrics and §§Department of Preventive Medicine, University Hospital of Vigo (Alvaro Cunqueiro Hospital), Vigo, Pontevedra, Spain; University Hospital Germans Trias i Pujol School of Medicine, Barcelona, Spain; Department of Microbiology, University Hospital of Vigo (Meixoeiro Hospital), Vigo, Spain; ††Department of Microbiology, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Barcelona, Spain; ‡‡Department of Microbiology, Santa Creu i Sant Pau Hospital, Barcelona, Spain; and ¶¶National Centre for Epidemiology, Institute of Health “Carlos III” and CIBERESP, Madrid, Spain.

Accepted for publication January 26, 2017.

The authors have no funding or conflicts of interest to disclose.

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Address for correspondence: María Cabrerizo, PhD, Enterovirus Unit, National Centre for Microbiology, Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain. E-mail:

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