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Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay

Pírez, María Catalina MD*; Mota, María Inés MD; Giachetto, Gustavo MD*; Sánchez Varela, Mercedes MD; Galazka, Jeannette MD§; Gutierrez, Stella MD; Varela, Adriana MD; Picón, Teresa MD§; Algorta, Gabriela MD

Pediatric Infectious Disease Journal: October 2017 - Volume 36 - Issue 10 - p 1000–1001
doi: 10.1097/INF.0000000000001671
Vaccine Reports

This is the first study showing the impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in Latin America; a significant (63.5%) reduction in hospitalization was observed during the first 6 years after starting vaccination. A 90% reduction of pneumococcal conjugate vaccines 7/13 serotypes was observed (P < 0.0001). After vaccination, all strains were penicillin susceptible. Mortality had a reduction of 71%.

From the *Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República; Departamento de Pediatría, British Hospital; §Departamento de Atención Integral del Niño, Niña y Adolescente, Asociación Española Primera en Salud; Centro Asistencial Sindicato Médico del Uruguay and ¥Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.

Accepted for publication June 18, 2017.

The authors have no funding or conflicts of interest to disclose.

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Address for correspondence: María Catalina Pírez, MD, Centro Hospitalario Pereira Rossell, Boulevard Artigas 1550 Montevideo 11600, Uruguay. E-mail:

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