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Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay

Pírez, María Catalina MD*; Mota, María Inés MD; Giachetto, Gustavo MD*; Sánchez Varela, Mercedes MD; Galazka, Jeannette MD§; Gutierrez, Stella MD; Varela, Adriana MD; Picón, Teresa MD§; Algorta, Gabriela MD

Pediatric Infectious Disease Journal: October 2017 - Volume 36 - Issue 10 - p 1000–1001
doi: 10.1097/INF.0000000000001671
Vaccine Reports

This is the first study showing the impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in Latin America; a significant (63.5%) reduction in hospitalization was observed during the first 6 years after starting vaccination. A 90% reduction of pneumococcal conjugate vaccines 7/13 serotypes was observed (P < 0.0001). After vaccination, all strains were penicillin susceptible. Mortality had a reduction of 71%.

From the *Facultad de Medicina, Universidad de la República. Hospital Pediátrico, Centro Hospitalario Pereira Rossell; Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell. Facultad de Medicina, Universidad de la República; Departamento de Pediatría, British Hospital; §Departamento de Atención Integral del Niño, Niña y Adolescente, Asociación Española Primera en Salud; Centro Asistencial Sindicato Médico del Uruguay and ¥Laboratorio de Microbiología, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay.

Accepted for publication June 18, 2017.

The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: María Catalina Pírez, MD, Centro Hospitalario Pereira Rossell, Boulevard Artigas 1550 Montevideo 11600, Uruguay. E-mail: mcpirez@yahoo.com.

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