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Complicated and Protracted Cryptococcal Disease in HIV-infected Children

Hassan, Haseena FCPaed*; Cotton, Mark F. FCPaed, PhD*†; Rabie, Helena MMed, MSc*†

Pediatric Infectious Disease Journal: January 2015 - Volume 34 - Issue 1 - p 62–65
doi: 10.1097/INF.0000000000000480
HIV Reports

We report 7 HIV-infected children with cryptococcosis. Median age and CD4 counts were 9.3 years and 12 cells/mm3, respectively. Two children died early. Of 4 children requiring prolonged amphotericin B and fluconazole at a dosage above 12 mg/kg/d, 3 presented with meningitis and 1 with fever. Immune reconstitution inflammatory syndrome contributed to morbidity through exacerbations at the primary site and elsewhere.

From the *Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children’s Hospital; and Children’s Infectious Diseases Research Unit (KIDCRU), Stellenbosch University, Tygerberg, Cape Town, South Africa.

Accepted for publication June 22, 2014.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Haseena Hassan, FCPaed, Department of Paediatrics and Child Health, Tygerberg Children’s Hospital, Parow 7505, South Africa. E-mail: hassan@sun.ac.za.

© 2015 by Lippincott Williams & Wilkins, Inc.