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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000453
HIV Reports

Nevirapine Concentrations in Preterm and Low Birth Weight HIV-Exposed Infants: Implications for Dosing Recommendations

de Waal, Reneé MBChB*; Kroon, S. Max MBChB, FCPaed; Holgate, Sandi L. MBChB, FCPaed; Horn, Alan R. MBChB, FCPaed, PhD; Tooke, Lloyd J. MBChB, MMed, FCPaed; Norman, Jennifer MSc*; Smith, Peter PhD*; Blockman, Marc MBChB, BPharm, MMed*; Cotton, Mark F. MMed, FCPaed, PhD; McIlleron, Helen M. MBChB, PhD*; Cohen, Karen MBChB, MMed, MSc*

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Abstract

World Health Organisation guidelines recommend nevirapine 2 mg/kg/d for HIV-exposed infants <2 kg, but 4–6 mg/kg/d for infants >2 kg. In 116 low birth weight infants, nevirapine 2 mg/kg/d until 14 days, and 4 mg/kg/d thereafter, was safe (1 mild possibly related rash) and achieved target plasma concentrations. Concentrations decreased with treatment duration. Routine dose increase at 14 days should be considered.

Copyright © 2014 by Lippincott Williams & Wilkins

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