Skip Navigation LinksHome > December 2014 - Volume 33 - Issue 12 > Nevirapine Concentrations in Preterm and Low Birth Weight HI...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000453
HIV Reports

Nevirapine Concentrations in Preterm and Low Birth Weight HIV-Exposed Infants: Implications for Dosing Recommendations

de Waal, Reneé MBChB*; Kroon, S. Max MBChB, FCPaed; Holgate, Sandi L. MBChB, FCPaed; Horn, Alan R. MBChB, FCPaed, PhD; Tooke, Lloyd J. MBChB, MMed, FCPaed; Norman, Jennifer MSc*; Smith, Peter PhD*; Blockman, Marc MBChB, BPharm, MMed*; Cotton, Mark F. MMed, FCPaed, PhD; McIlleron, Helen M. MBChB, PhD*; Cohen, Karen MBChB, MMed, MSc*

Collapse Box

Abstract

World Health Organisation guidelines recommend nevirapine 2 mg/kg/d for HIV-exposed infants <2 kg, but 4–6 mg/kg/d for infants >2 kg. In 116 low birth weight infants, nevirapine 2 mg/kg/d until 14 days, and 4 mg/kg/d thereafter, was safe (1 mild possibly related rash) and achieved target plasma concentrations. Concentrations decreased with treatment duration. Routine dose increase at 14 days should be considered.

© 2014 by Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.