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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000422
Brief Reports

Insights into Pediatric Herpes Simplex Encephalitis From a Cohort of 21 Children From the California Encephalitis Project, 1998–2011

To, Tu M. MPH*†‡; Soldatos, Ariane MD§; Sheriff, Heather; Schmid, D. Scott PhD; Espinosa, Natasha; Cosentino, Giorgio; Preas, Christopher P.; Glaser, Carol A. DVM, MPVM, MD

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Abstract

Twenty-one children with confirmed herpes simplex encephalitis were identified in the California Encephalitis Project. Noteworthy features included 6 (29%) patients with an initial negative herpes simplex virus cerebrospinal fluid polymerase chain reaction test and 13 (59%) patients with extratemporal lobe involvement identified by neuroimaging. Eleven cases were <4 years of age, but all 4 fatal cases occurred in adolescents.

Copyright © 2014 by Lippincott Williams & Wilkins

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