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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000422
Brief Reports

Insights into Pediatric Herpes Simplex Encephalitis From a Cohort of 21 Children From the California Encephalitis Project, 1998–2011

To, Tu M. MPH*†‡; Soldatos, Ariane MD§; Sheriff, Heather; Schmid, D. Scott PhD; Espinosa, Natasha; Cosentino, Giorgio; Preas, Christopher P.; Glaser, Carol A. DVM, MPVM, MD

Supplemental Author Material
Erratum

Erratum

In the article on page 1287, volume 33, issue 12, there are number and percentage errors in the text and Table 1. In the abstract the second sentence should appear as “Noteworthy features included 6 (29%) patients with an initial negative herpes simplex virus cerebrospinal fluid polymerase chain reaction test and 13 (62%) patients with extratemporal lobe involvement identified by neuroimaging.” In the first paragraph of the Results section, the third sentence should appear as “Nine (43%) patients were Hispanic, 5 (24%) White and 4 (19%) Asian/Pacific Islander.” The third paragraph of Results section, should appear as below:

Neuroimaging [computed tomography (CT) scan and magnetic resonance imaging (MRI)] was abnormal in many patients: 20 (95%) for MRI and 13 (68%) for CT scans (Table 1). The MRI findings showed 7 patients had isolated temporal lobe involvement, 9 had temporal and extratemporal lobe involvement and 4 had exclusively extratemporal lobe involvement. Overall, neuroimaging identified 13 (62%) patients with extratemporal lobe involvement (including those with simultaneous temporal and extratemporal abnormalities). A hemorrhagic component was seen in 5 (23%) patients. For the 15 patients with EEG testing, 13 (87%) were abnormal. Eight (53%) of these 15 patients had diffuse or multifocal slowing in their EEG, 2 (13%) had periodic lateralized epileptiform discharges and 3 (20%) had temporal epileptiform activity.

In the fourth paragraph of the Results section, the first sentence should appear as “Of the 21 patients, 4 (19%) died during their hospitalization despite receiving acyclovir treatment at time of admission.” The corrected table appears below.

The Pediatric Infectious Disease Journal. 34(9):960, September 2015.

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Abstract

Twenty-one children with confirmed herpes simplex encephalitis were identified in the California Encephalitis Project. Noteworthy features included 6 (29%) patients with an initial negative herpes simplex virus cerebrospinal fluid polymerase chain reaction test and 13 (59%) patients with extratemporal lobe involvement identified by neuroimaging. Eleven cases were <4 years of age, but all 4 fatal cases occurred in adolescents.

© 2014 by Lippincott Williams & Wilkins, Inc.

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