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Diagnosis and Treatment of Tuberculosis Among Children at an HIV Care Program in Dar es Salaam, Tanzania

Adams, Lisa V. MD*; McQuillan, Thomas BA; Naburi, Helga E. MD; Lyatuu, Goodluck MD§; Ippolito, Matthew M. MD; Saunders, Andrew MD; Kiravu, Anna MD**; Palumbo, Paul MD*; von Reyn, C. Fordham MD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000452
HIV Reports
Abstract

Diagnosis and treatment of tuberculosis is challenging in children with human immunodeficiency virus (HIV) infection. We describe the clinical features, diagnostic testing results, tuberculosis and HIV treatment and clinical outcomes of 57 HIV-infected children diagnosed with tuberculosis at the DarDar Pediatric Program in Dar es Salaam, Tanzania. In this cohort, tuberculosis was common, microbiologic studies were frequently negative and mortality was high.

Author Information

From the *Infectious Disease and International Health Section, Geisel School of Medicine at Dartmouth; Dartmouth College, Hanover, NH; Muhimbili University of Health and Allied Sciences; §Management and Development for Health, Dar es Salaam, Tanzania; Departments of Medicine and Pediatrics, University of California at San Francisco, San Francisco, CA; and **DarDar Pediatric Program, Dar es Salaam, Tanzania.

Accepted for publication May 7, 2014.

This work was supported by the National Institutes of Health, Fogarty International Center (D43-TW006807) and The Foundation for Treatment of Children with AIDS, New York. The authors have no other funding or conflict of interest to disclose.

Address for correspondence: Lisa V. Adams, MD, Associate Dean for Global Health, The Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Room 219, Hanover, NH 03755. E-mail: Lisa.V.Adams@Dartmouth.edu.

© 2014 by Lippincott Williams & Wilkins, Inc.