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Once-daily Antiretroviral Therapy in a Cohort of HIV-Infected Children and Adolescents

Jiménez-Montero, Beatriz MD*; Beceiro, José MD; de José-Gómez, M. Isabel MD; González-Tomé, M. Isabel MD§; Gurbindo-Gutierrez, Dolores MD; Martínez-Pérez, Jorge MD; Mellado-Peña, M. José MD**; Navarro-Gómez, M. Luisa MD††; Roa-Francia, Miguel A. MD‡‡; Rojo-Conejo, Pablo MD§; Saavedra-Lozano, Jesús MD††; de Ory, Santiago Jiménez MSc§§; Ramos-Amador, José T. MD¶¶; on behalf of Madrid Cohort of HIV-Infected Children and from the working groups of CoRISpe

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000367
HIV Reports
Abstract

We evaluated the evolution over time of once-daily antiretroviral therapy in HIV-infected children and its relationship with adherence. An increase on the prevalence of once-daily antiretroviral therapy was observed over time (from 0.9% in 2002 to 44.2% in 2011). There was no difference in adherence regarding once-daily or BID regimens in 2011. Adherence was related to age and pill burden.

Author Information

From the *Pediatrics Department, Hospital Infanta Sofía, San Sebastián de los Reyes; Pediatrics Department, Hospital Principe de Asturias, Alcalá de Henares; Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Universitario La Paz; §Division of Pediatric Infectious Diseases, Hospital Universitario 12 de Octubre; Pediatric Immunology Department, Hospital General Universitario Gregorio Marañón; Pediatrics Department, Hospital Universitario Niño Jesús; **Pediatric Infectious Diseases Department, Hospital Carlos III; ††Division of Pediatric Infectious Diseases, Hospital Universitario Gregorio Marañón; ‡‡Pediatrics Department, Hospital de Móstoles, Madrid; §§Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and ¶¶Pediatrics Department, Hospital Universitario de Getafe, Madrid, Spain.

Accepted for publication March 11, 2014.

This work was supported in part by grants from Fundación para la Investigación y Prevención de SIDA en España (FIPSE; grants no. 360829/09 and 361910/10) and Red Temática de Investigación Cooperativa Sanitaria ISCIII (RED RIS; RD06/0006/0035 and RD06/0006/0021). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Beatriz Jiménez-Montero, C/Violeta 15, 28760 Tres Cantos, Madrid, Spain. E-mail address: b.jimenez.montero@gmail.com.

© 2014 by Lippincott Williams & Wilkins, Inc.