We evaluated the evolution over time of once-daily antiretroviral therapy in HIV-infected children and its relationship with adherence. An increase on the prevalence of once-daily antiretroviral therapy was observed over time (from 0.9% in 2002 to 44.2% in 2011). There was no difference in adherence regarding once-daily or BID regimens in 2011. Adherence was related to age and pill burden.
From the *Pediatrics Department, Hospital Infanta Sofía, San Sebastián de los Reyes; †Pediatrics Department, Hospital Principe de Asturias, Alcalá de Henares; ‡Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Universitario La Paz; §Division of Pediatric Infectious Diseases, Hospital Universitario 12 de Octubre; ¶Pediatric Immunology Department, Hospital General Universitario Gregorio Marañón; ‖Pediatrics Department, Hospital Universitario Niño Jesús; **Pediatric Infectious Diseases Department, Hospital Carlos III; ††Division of Pediatric Infectious Diseases, Hospital Universitario Gregorio Marañón; ‡‡Pediatrics Department, Hospital de Móstoles, Madrid; §§Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), and ¶¶Pediatrics Department, Hospital Universitario de Getafe, Madrid, Spain.
Accepted for publication March 11, 2014.
This work was supported in part by grants from Fundación para la Investigación y Prevención de SIDA en España (FIPSE; grants no. 360829/09 and 361910/10) and Red Temática de Investigación Cooperativa Sanitaria ISCIII (RED RIS; RD06/0006/0035 and RD06/0006/0021). The authors have no other funding or conflicts of interest to disclose.
Address for correspondence: Beatriz Jiménez-Montero, C/Violeta 15, 28760 Tres Cantos, Madrid, Spain. E-mail address: firstname.lastname@example.org.