We evaluated whether procalcitonin (PCT) might aid diagnosing serious bacterial infections in a general pediatric intensive care unit population. Two-hundred and one patients accounted for 332 PCT samples. A PCT ≥1.45 ng/mL had a positive predictive value of 30%, a negative predictive value of 93% and a sensitivity of 72% and a specificity of 75%. These data suggest PCT can assist in identifying patients without serious bacterial infections and limit antimicrobial use.
From the *St. Christopher’s Hospital for Children, Philadelphia, PA; †Drexel University College of Medicine, Philadelphia, PA; ‡Alfred I duPont Hospital for Children, Wilmington, DE; §NYU Langone Medical Center, New York, NY; and ¶NYU School of Medicine, New York, NY.
Accepted for publication April 4, 2014.
This work, in part, was presented as an abstract at the 22nd Annual Pediatric Pharmacy Advocacy Group Meeting Indianapolis, IN, May 2013.
The authors have no funding or conflicts of interest to disclose.
Address for correspondence: Jeffrey J. Cies, PharmD, MPH, BCPS-AQ ID, Critical Care and Infectious Diseases Clinical Pharmacist, St. Christopher’s Hospital for Children, 3601 A Street, Philadelphia, PA 19134-1095. E-mail: firstname.lastname@example.org.