After exposure to a teacher with multidrug-resistant pulmonary tuberculosis, 31 children developed latent infection. Twenty-six were treated with levofloxacin and pyrazinamide. Twelve required a change in therapy secondary to adverse effects. The most common adverse effects included abdominal pain, arthralgias/myalgias and elevated transaminases. All children reported at least 1 adverse effect. Fifteen children completed treatment. All adverse effects were transient.
From the *Infectious Diseases, Children’s Hospital Orange County, Orange; and † County of Orange Health Care Agency, Santa Ana, CA.
Accepted for publication December 23, 2014.
The authors have no funding or conflicts of interest to disclose
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Address for correspondence: Felice C. Adler-Shohet, MD, Infectious Diseases, Children’s Hospital of Orange County, 1201 West La Veta Avenue, Orange, CA 92868–3874. E-mail: firstname.lastname@example.org.