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Would Parents Consent To A Comparative Effectiveness Trial Of Oral Doxycycline Versus Intravenous Ceftriaxone For The Treatment Of Children With Lyme Meningitis?

Garro Aris MD MPH; Koster, Michael MD; LaRue, Molly BA; Hipolito, Evelyn BA; Congdon, Elizabeth BA; Burnett, Kathleen; Cullen, Nicole; Nigrovic, Lise E. MD, MPH
The Pediatric Infectious Disease Journal: Post Acceptance: September 28, 2017
doi: 10.1097/INF.0000000000001793
Brief Reports: PDF Only

Children with Lyme meningitis are often treated with intravenous ceftriaxone although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) would consent to their child participating. Parents would accept 2 additional days of symptoms (non-inferiority margin) with doxycycline even if ceftriaxone hastened symptom resolution.

Reprints available on request to corresponding author at address above

Disclosure of Funding Support: None

Corresponding author: Aris Garro, MD, 125 Whipple Street, UEMF Suite, 3rd floor, Providence, RI 02908, Telephone: 401-480-8682, Email:

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