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Optimizing Blood Collection and Processing for QuantiFERON-TB Gold-In Tube Testing Gives Low Rates of Indeterminate Results: Clinical Implications.

Kordy, Faisal MD; Waters, Valerie MD; Den-Hollander, Cathy BSc; Read, Stanley MD; Lam, Ray PHC-NP; Kitai, Ian MD
Pediatric Infectious Disease Journal: Post Acceptance: August 2, 2017
doi: 10.1097/INF.0000000000001732
Brief Reports: PDF Only

The rate of low-mitogen indeterminate interferon-gamma release assay (IGRA) results at a hospital with expert pediatric phlebotomy and rapid incubation of specimens was 0.96%. All low-mitogen indeterminate results were found to be associated with immunocompromised or anergic state. We describe a child where an unexpected indeterminate IGRA test pointed to an underlying anergic condition and was of diagnostic significance.

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