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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000453
HIV Reports: PDF Only

Nevirapine Concentrations in Preterm and Low Birth Weight HIV-Exposed Infants: Implications for Dosing Recommendations.

de Waal, Reneé MBChB; Kroon, S. Max MBChB, FCPaed; Holgate, Sandi L. MBChB, FCPaed; Horn, Alan R. MBChB, FCPaed, PhD; Tooke, Lloyd J. MBChB, MMed, FCPaed; Norman, Jennifer MSc; Smith, Peter PhD; Blockman, Marc MBChB, BPharm, MMed; Cotton, Mark F. MMed, FCPaed, PhD; McIlleron, Helen M. MBChB, PhD; Cohen, Karen MBChB, MMed, MSc

Published Ahead-of-Print
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Abstract

World Health Organisation guidelines recommend nevirapine 2 mg/kg/day for HIV-exposed infants <2kg, but 4-6 mg/kg/day for infants >2kg. In 116 low birth weight infants, nevirapine 2 mg/kg/day until 14 days, and 4 mg/kg/day thereafter, was safe (one mild possibly-related rash) and achieved target plasma concentrations. Concentrations decreased with treatment duration. Routine dose increase at 14 days should be considered.

(C) 2014 by Lippincott Williams & Wilkins, Inc.

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