World Health Organisation guidelines recommend nevirapine 2 mg/kg/day for HIV-exposed infants <2kg, but 4-6 mg/kg/day for infants >2kg. In 116 low birth weight infants, nevirapine 2 mg/kg/day until 14 days, and 4 mg/kg/day thereafter, was safe (one mild possibly-related rash) and achieved target plasma concentrations. Concentrations decreased with treatment duration. Routine dose increase at 14 days should be considered.
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