Institutional members access full text with Ovid®

Share this article on:

Metabolic Abnormalities and Clinical Lipodystrophy in Children with Human Immunodeficiency Virus Infection: A Report from A Tertiary-Care-Center in India.

Kumar, Prasanna MD; Suri, Deepti MD; Vignesh, Pandiarajan MD; Attri, Savita Verma MD; Bhalla, Anil Kumar PhD; Singh, Surjit MD
Pediatric Infectious Disease Journal: Post Acceptance: August 3, 2017
doi: 10.1097/INF.0000000000001738
HIV Reports: PDF Only

A cross-sectional study from a tertiary-care-center in India was undertaken to assess and compare the prevalence of blood glucose and lipid profile aberrations in children who received first-line anti-retroviral therapy (ART) (n=63) and in children who were naive to ART (n=46).

Impaired fasting blood glucose values were found in 7 children in ART-experienced group but none in ART-naive group (p=0.02). Low concentrations of high-density lipoprotein (HDL) cholesterol were more prevalent in the ART-naive group compared with ART-experienced group (54.3% vs. 22.2%, p=0.001). Hypertriglyceridemia was noted in a significant proportion of both ART-naive (43.5%) and ART-experienced children (39.7%). Incidence of clinical lipodystrophy (LD) was 47.7% and there was no significant association noted between lipid profile abnormalities and LD.

Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.