Skip Navigation LinksHome > Published Ahead-of-Print > Low Mortality of Staphylococcus aureus Bacteremia in Iceland...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000485
Original Studies: PDF Only

Low Mortality of Staphylococcus aureus Bacteremia in Icelandic Children - Nationwide Study on Incidence and Outcome.

Asgeirsson, Hilmir MD; Gudlaugsson, Olafur MD; Kristinsson, Karl G. MD, PhD; Vilbergsson, Gauti R. MD; Heiddal, Sigurdur MD; Haraldsson, Asgeir MD, PhD; Weiland, Ola MD, PhD; Kristjansson, Mar MD

Published Ahead-of-Print
Collapse Box


Background: Staphylococcus aureus is a major cause of blood stream infections, but population based studies on pediatric S. aureus bacteremia (SAB) are sparse. The objective of the study was to evaluate the incidence and mortality of SAB in Icelandic children over time, and to assess the proportions of nosocomial and health-care associated infections.

Methods: Children <18 years with positive blood cultures for S. aureus from January 1995 through December 2011 were identified retrospectively at the clinical microbiology laboratories performing blood cultures in Iceland. Clinical data were collected from medical records.

Results: In total 140 children had 146 distinct episodes of SAB. Bacteremia-related mortality was 0.7% (1/146), all cause 30-day mortality, 1.4% (2/146), and one-year mortality, 3.6% (5/140). The annual incidence of SAB was 10.9 /100,000 children, decreasing by 36% from 13.1 /100,000 in 1995-2003 to 8.4 /100,000 in 2004-2011 (p<0.001). At the same time the annual number of blood cultures analyzed at the main study site decreased from 1529 to 1143 (25%). SAB incidence was highest in infants (<1 year), 58.8 /100,000. Of 146 episodes 50 (34%) were nosocomial, 21 (14%) health-care associated, and 75 (51%) community acquired. No methicillin-resistant S. aureus isolate was identified.

Conclusions: In this nationwide study on pediatric SAB the case fatality ratio was very low. A decreasing incidence was seen, possibly related to fewer blood cultures being collected. Nosocomial and health-care associated infections accounted for 50% of the cases. The findings provide useful information on the epidemiology and outcome of SAB in children.

(C) 2014 by Lippincott Williams & Wilkins, Inc.


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.