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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000422
Brief Reports: PDF Only

Insights into Pediatric Herpes Simplex Encephalitis from a Cohort of 21 Children from the California Encephalitis Project, 1998-2011.

To, Tu M. MPH; Soldatos, Ariane MD; Sheriff, Heather; Schmid, D. Scott PhD; Espinosa, Natasha; Cosentino, Giorgio; Preas, Christopher P.; Glaser, Carol A. DVM, MPVM, MD

Published Ahead-of-Print
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Abstract

Twenty-one children with confirmed herpes simplex encephalitis were identified in the California Encephalitis Project. Noteworthy features included six (29%) patients with an initial negative herpes simplex virus CSF PCR test and 13 (59%) patients with extra-temporal lobe involvement identified by neuroimaging. Eleven cases were <4 years of age, but all four fatal cases occurred in adolescents.

(C) 2014 by Lippincott Williams & Wilkins, Inc.

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