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Serotypes not Included in 13-Valent Pneumococcal Vaccine as Causes of Acute Otitis Media with Spontaneous Tympanic Membrane Perforation in a Geographic Area with High Vaccination Coverage

Marchisio, Paola MD*; Esposito, Susanna MD*; Picca, Marina MD; Baggi, Elena MD*; Terranova, Leonardo BSc*; Orenti, Annalisa BSc*‡; Biganzoli, Elia MD; Principi, Nicola MD*; for the Milan AOM Study Group

Pediatric Infectious Disease Journal: May 2017 - Volume 36 - Issue 5 - p 521–523
doi: 10.1097/INF.0000000000001485
Brief Reports

In 177 children living in an area with high 13-valent pneumococcal conjugate vaccine 13 coverage, who had acute otitis media complicated with spontaneous tympanic membrane perforation, Streptococcus pneumoniae was identified in the middle ear fluid of 48 (27.1%) subjects, with 37 (77.1%) cases caused by nonpneumococcal conjugate vaccine 13 serotypes.

From the *Department of Pathophysiology and Transplantation, Pediatric Highly Intensive Care Unit, Università degli Studi di Milan, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Primary Care Pediatrician, Milan, Italy; and Department of Clinical Sciences and Community Health, Unit of Medical Statistics, Biometry and Bioinformatics “G.A. Maccacaro,” Università degli Studi di Milan, Milan, Italy.

Accepted for publication October 12, 2016.

This study was supported by a grant from the Italian Ministry of Health (Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Ricerca Corrente Grant 2016 850/01).

The authors have no conflicts of interest to disclose.

Address for correspondence: Susanna Esposito, MD, Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milan, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy. E-mail: susanna.esposito@unimi.it.

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