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Microcephaly Case Fatality Rate Associated with Zika Virus Infection in Brazil: Current Estimates

Cunha, Antonio José Ledo Alves da MD, PhD*; de Magalhães-Barbosa, Maria Clara MD, PhD; Lima-Setta, Fernanda MSc; Medronho, Roberto de Andrade MD, PhD; Prata-Barbosa, Arnaldo MD, PhD*†

Pediatric Infectious Disease Journal: May 2017 - Volume 36 - Issue 5 - p 528–530
doi: 10.1097/INF.0000000000001486
Brief Reports

Considering the currently confirmed cases of microcephaly and related deaths associated with Zika virus in Brazil, the estimated case fatality rate is 8.3% (95% confidence interval: 7.2–9.6). However, a third of the reported cases remain under investigation. If the confirmation rates of cases and deaths are the same in the future, the estimated case fatality rate will be as high as 10.5% (95% confidence interval: 9.5–11.7).

From the *Departamento de Pediatria da Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Rio de Janeiro, Brazil; Departamento de Pediatria, Instituto D’Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil; and Departamento de Medicina Preventiva, Instituto de Estudos em Saúde Coletiva (IESC) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Accepted for publication November 30, 2016.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Maria Clara de Magalhães-Barbosa, MD, PhD, Instituto D’Or de Pesquisa e Ensino (IDOR), Rua Diniz Cordeiro 30, Rio de Janeiro, RJ, Brazil. E-mail:

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