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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000335
Antimicrobial Reports

Safety and Tolerability of High-dose Weekly Liposomal Amphotericin B Antifungal Prophylaxis

Hand, Elizabeth O. PharmD, BCPS*†‡; Ramanathan, Meenakshi R. PharmD*†§

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Abstract

Children with hematologic malignancies are at an increased risk of invasive fungal infections and a greater risk has been seen with exposure to building construction. Prophylaxis with high-dose (IV) liposomal amphotericin B (L-AmB) 10 mg/kg once weekly was initiated in our high risk children based on previous pharmacokinetic studies. This treatment regimen was associated with a 26% incidence of adverse infusion reactions.

Copyright © 2014 by Lippincott Williams & Wilkins

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