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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000336
Brief Reports

Acquired Drug Resistance During Inadequate Therapy in A Young Child with Tuberculosis

Garcia-Prats, Anthony J. MD*; Willemse, Marianne MB, ChB; Seifart, Heiner I. PhD; Jordaan, Annemie M. Med Tech§; Werely, Cedric J. PhD§; Donald, Peter R. MD*; Schaaf, H. Simon MMed (Paed), MD (Paed)

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Abstract

Drug resistance in children with tuberculosis is usually primary (transmitted); however, resistance acquisition during treatment is possible. We describe a child with tuberculosis who acquired drug resistance while receiving directly observed but inadequate first-line therapy and the programmatic and clinical factors that may have contributed to resistance acquisition.

Copyright © 2014 by Lippincott Williams & Wilkins

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