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Garcia-Prats, Anthony J. MD*; Willemse, Marianne MB, ChB†; Seifart, Heiner I. PhD‡; Jordaan, Annemie M. Med Tech§; Werely, Cedric J. PhD§; Donald, Peter R. MD*; Schaaf, H. Simon MMed (Paed), MD (Paed)*¶
Drug resistance in children with tuberculosis is usually primary (transmitted); however, resistance acquisition during treatment is possible. We describe a child with tuberculosis who acquired drug resistance while receiving directly observed but inadequate first-line therapy and the programmatic and clinical factors that may have contributed to resistance acquisition.
© 2014 by Lippincott Williams & Wilkins, Inc.
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tuberculosis, children, isoniazid monoresistance, acquired antibiotic resistance, multidrug resistance
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