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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000264
Original Studies

The Management and Outcome of Spinal Implant-related Infections in Pediatric Patients: A Retrospective Review

Messina, Allison F. MD*; Berman, David M. DO*; Ghazarian, Sharon R. PhD; Patel, Ravi*; Neustadt, Jeffrey MD; Hahn, Gregory MD; Sibinga, Erica M. S. MD, MHS

Supplemental Author Material
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Abstract

Background:

Infection after implantation of spinal rods is a significant complication of this procedure. Optimal treatment of surgical implants often involves device removal. This approach is problematic when treating spinal implant-related infections, because device removal may cause significant morbidity. Medical management of these infections is therefore necessary, but treatment regimens are not standardized. We conducted a retrospective review of pediatric patients with spinal implant-related infections at a regional spinal center for a 6-year period. We describe clinical course, duration of treatment and outcomes.

Methods:

We reviewed records of patients with spinal implant-related infections from 2005 to 2010. Data collection included demographics, underlying diagnosis, surgical hardware, timing to infection after implantation, signs and symptoms of infection, duration of antimicrobials, adverse drug events and long-term outcomes.

Results:

We enrolled 23 patients with spinal implant infections, aged 8–20 years. Wound drainage was the most common presenting symptom (82.6%). Median time from surgery to first infection was 16 days (range: 8–1052 days). Median length of antimicrobial therapy was 131 days (range: 42–597 days). Seventy eight percent were cured with antibiotics alone with implanted devices retained. Four patients failed medical therapy and required device removal. A wide range of antibiotic duration was used (42 to >597 days). Seven patients (30.4%) experienced at least 1 adverse drug event.

Conclusions:

Infection related to spinal instrumentation procedures can be managed medically with long-term antibiotic therapy. Careful monitoring for not only efficacy but also adverse drug events is advised. Further research is needed to determine the optimal duration of antibiotics for spinal implant-related infections.

Copyright © 2014 by Lippincott Williams & Wilkins

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