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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000268
Antimicrobial Reports

Clinical Evaluation of Vancomycin Dosage in Pediatric Oncology Patients

Sanders, Stefan J.W.J. PharmD*; Bijleveld, Yuma A. PharmD*; Sinkeler, Fleur BSc*; Kemper, Elles M. PharmD, PhD*; Pajkrt, Dasja MD, PhD, MBA; van de Wetering, Marianne MD, PhD; van Eijkelenburg, Natasha K.A. MD; Mathôt, Ron A.A. PharmD, PhD*

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Abstract

Vancomycin trough serum concentrations were below therapeutic range (8–15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

Copyright © 2014 by Lippincott Williams & Wilkins

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