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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000143
HIV Reports

Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children

Fillekes, Quirine MSc*; Kendall, Lindsay MSc; Kitaka, Sabrina MB ChB; Mugyenyi, Peter MD, FCRP§; Musoke, Philippa PhD; Ndigendawani, Milly MB ChB§; Bwakura-Dangarembizi, Mutsa MB ChB; Gibb, Diana M. MB ChB, MSc, MD; Burger, David PharmD, PhD*; Walker, Ann Sarah PhD

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Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6–6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0–12h was 3.0, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.
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Copyright © 2014 by Lippincott Williams & Wilkins


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