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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000143
HIV Reports

Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children

Fillekes, Quirine MSc*; Kendall, Lindsay MSc; Kitaka, Sabrina MB ChB; Mugyenyi, Peter MD, FCRP§; Musoke, Philippa PhD; Ndigendawani, Milly MB ChB§; Bwakura-Dangarembizi, Mutsa MB ChB; Gibb, Diana M. MB ChB, MSc, MD; Burger, David PharmD, PhD*; Walker, Ann Sarah PhD

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Abstract

Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6–6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0–12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underweight children. Higher exposure was also marginally associated with lower hemoglobin.
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Copyright © 2014 by Lippincott Williams & Wilkins

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