Chronic granulomatous disease is a rare primary immunodeficiency caused by phagocytic cell defect. We describe the case of 43-month-old boy with chronic granulomatous disease presenting with Salmonella spp brain abscesses, together with a review of the 13 cases reported in the literature.
From the *Unit of Immunology and Infectious Diseases, University-Hospital Pediatric Department; †Unit of Radiology, Bambino Gesù Children Hospital, IRCCS; ‡Department of Public Health and Cellular Biology, Tor Vergata University, Rome; and §Pediatric Immunohematology and Bone Marrow Transplant Unit and San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), HS Raffaele Scientific Institute, Milan, Italy.
Accepted for publication December 31, 2013.
The authors were supported in part by grant CELL PID (HEALTH-F5-2010–261387 to AA) and E-RARE. The authors have no other funding or conflicts of interest to disclose.
Address for correspondence: Dr. Andrea Finocchi, MD, PhD, Unit of Immunology and Infectious Diseases, University Hospital Department of Pediatrics, Bambino Gesù Children’s Hospital and University of Rome “Tor Vergata,” Piazza Sant’Onofrio, 4 00165 Rome, Italy. E-mail: email@example.com.