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Chronic Granulomatous Disease Presenting With Salmonella Brain Abscesses

Finocchi, Andrea MD, PhD*; Claps, Alessia MD*; Serafinelli, Jessica MD*; Salfa, Irene MD*; Longo, Daniela MD; Di Matteo, Gigliola BSc, PhD; Aiuti, Alessandro MD, PhD; Rossi, Paolo MD, PhD*

Pediatric Infectious Disease Journal: May 2014 - Volume 33 - Issue 5 - p 525–528
doi: 10.1097/INF.0000000000000270
Immunology Reports

Chronic granulomatous disease is a rare primary immunodeficiency caused by phagocytic cell defect. We describe the case of 43-month-old boy with chronic granulomatous disease presenting with Salmonella spp brain abscesses, together with a review of the 13 cases reported in the literature.

From the *Unit of Immunology and Infectious Diseases, University-Hospital Pediatric Department; Unit of Radiology, Bambino Gesù Children Hospital, IRCCS; Department of Public Health and Cellular Biology, Tor Vergata University, Rome; and §Pediatric Immunohematology and Bone Marrow Transplant Unit and San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), HS Raffaele Scientific Institute, Milan, Italy.

Accepted for publication December 31, 2013.

The authors were supported in part by grant CELL PID (HEALTH-F5-2010–261387 to AA) and E-RARE. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Dr. Andrea Finocchi, MD, PhD, Unit of Immunology and Infectious Diseases, University Hospital Department of Pediatrics, Bambino Gesù Children’s Hospital and University of Rome “Tor Vergata,” Piazza Sant’Onofrio, 4 00165 Rome, Italy. E-mail: andrea.finocchi@uniroma2.it.

© 2014 by Lippincott Williams & Wilkins, Inc.