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Blood Lactate in HIV-infected Children on Antiretroviral Therapy in Rural South Africa

van Ramshorst, Mette S. MD*; Struthers, Helen E. MSc*†; Mcintyre, James A. MB ChB, FRCOG*‡; Peters, Remco P.H. MD, PhD, MSc Epidemiol*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000036
HIV Reports

We studied blood lactate levels in 253 South African children on antiretroviral therapy. The prevalence of hyperlactatemia was 68% and severity was mild in most cases (69%). There was no association of symptoms and/or signs with hyperlactatemia. Independent predictors were lipo-dystrophy, time on antiretroviral therapy and baseline CD4 count. Increased awareness of hyperlactatemia in African children on antiretroviral therapy is warranted.

Author Information

From the *Anova Health Institute, Johannesburg and Tzaneen, South Africa; Department of Internal Medicine, University of Cape Town; and School of Public Health, University of Cape Town, Cape Town, South Africa.

Accepted for publication August 7, 2013.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: R.P.H. Peters, MD, PhD, MSc Epidemiol, Anova Health Institute, Khutso Kurhula Project, 21A Peace Street, P.O. Box 2243, 0850 Tzaneen, South Africa. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc.