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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000036
HIV Reports

Blood Lactate in HIV-infected Children on Antiretroviral Therapy in Rural South Africa

van Ramshorst, Mette S. MD*; Struthers, Helen E. MSc*†; Mcintyre, James A. MB ChB, FRCOG*‡; Peters, Remco P.H. MD, PhD, MSc Epidemiol*

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Abstract

We studied blood lactate levels in 253 South African children on antiretroviral therapy. The prevalence of hyperlactatemia was 68% and severity was mild in most cases (69%). There was no association of symptoms and/or signs with hyperlactatemia. Independent predictors were lipo-dystrophy, time on antiretroviral therapy and baseline CD4 count. Increased awareness of hyperlactatemia in African children on antiretroviral therapy is warranted.

Copyright © 2013 by Lippincott Williams & Wilkins

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