Share this article on:

The Clinical Burden And Predictors of Sequelae Following Invasive Meningococcal Disease In Australian Children

Wang, Bing MB BS*†; Clarke, Michelle AppSc(Med Lab), GDipSTC; Thomas, Natalie BHSc (Hons), LL.B, GDLP, MPH; Howell, Stuart BA (Hons), PhD§; Afzali, Hossein Haji Ali GDPH, MD, PhD; Marshall, Helen MB BS, MD, DCH, MPH†‖

The Pediatric Infectious Disease Journal: March 2014 - Volume 33 - Issue 3 - p 316–318
doi: 10.1097/INF.0000000000000043
Brief Reports

Of 109 children admitted to a tertiary paediatric hospital with a diagnosis of invasive meningococcal disease from 2000–2011, 37.6% (n = 41) developed sequelae; for serogroup B, 41.3% developed sequelae. Independent predictors of sequelae included: fever ≥ 39°C on hospital presentation [odds ratio (OR): 4.5; P = 0.012] and a diagnosis of septicemia with meningitis compared with septicemia alone (OR: 15.5; P < 0.001) and meningitis alone (OR: 7.8; P = 0.002).

From the *School of Population Health/Paediatrics and Reproductive Health, University of Adelaide; Vaccinology and Immunology Research Trials Unit (VIRTU), Women’s and Children’s Hospital; Vaccinology and Immunology Research Trials Unit (VIRTU), Women’s and Children’s Hospital, North Adelaide; §Data Management & Analysis Centre, Discipline of Public Health, University of Adelaide; Discipline of Public Health, University of Adelaide; and Career Development Fellow, Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia.

Accepted for publication August 28, 2013.

The study was partly supported by a grant from Novartis Vaccines and Diagnostics Pty Ltd to the Women’s and Children’s Hospital. The Vaccinology and Immunology Research Trials Unit (VIRTU) is the research organization that conducted this study. This was an investigator led study, designed and conducted independently of the sponsor with the analysis and writing of the publication completed by the listed authors.

Address for Correspondence: Ms Bing Wang, Vaccinology and Immunology Research Trials Unit (VIRTU), Women’s and Children’s Hospital, 72 King William Road, North Adelaide, South Australia 5006, Australia. E-mail: bing.wang@adelaide.edu.au.

© 2014 by Lippincott Williams & Wilkins, Inc.