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Impact of Unlabeled French Antibiotic Guidelines On Antibiotic Prescriptions For Acute Respiratory Tract Infections In 7 Pediatric Emergency Departments, 20092012

Angoulvant, François MD*†; Pereira, Miguel MD*; Perreaux, Francis MD; Soussan, Valerie MD§; Pham, Luu-Ly MD; Trieu, Thanh-Van MD; Cojocaru, Bogdan MD**; Guedj, Romain MD††; Cohen, Robert MD‡‡; Alberti, Corinne MD§§; Gajdos, Vincent MD†‡

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0000000000000125
Brief Reports
Abstract

From November 2009 to October 2012, implementation of guidelines, unlabeled by the French Agency of Health Products, changed the categories of antibiotics prescribed for acute respiratory tract infections in 7 pediatric emergency departments. During the study, 36,413 acute respiratory tract infections-related antibiotic prescriptions were prescribed. Amoxicillin prescriptions rose from 30.0% to 84.7%, while amoxicillin-clavulanate and cefpodoxime prescriptions decreased to 10.2% and 2.5%, respectively.

Author Information

From the *Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris; Inserm, CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development Team, Villejuif; Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Antoine Béclère and Université Paris 11, Clamart; §Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Ambroise Paré and Université Versailles-Saint-Quentin-en-Yvelines, Boulogne; Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Bicêtre and Université Paris 11, Kremlin-Bicêtre; ‖Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Jean Verdier and Université Paris 13, Bondy; ††Hôpitaux de Paris (APHP), Pediatric Department, Hôpital Louis Mourier and Université Paris 7 Denis Diderot, Colombes; ‡‡Hôpitaux de Paris (APHP), Pediatric Emergency Department, Hôpital Armand Trousseau and Université Paris 6 Descartes, Paris; §§Pediatric Department, Centre Hospitalier Intercommunal, Créteil; and ¶¶Hôpitaux de Paris (APHP), Clinical Epidemiologic Unit and INSERM CIE-5, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris, France.

Accepted for publication October 1, 2013.

F.A. received a travel grant from Pfizer, Inc. T.T. received a travel grant from GlaxoSmithKline Biologicals. F.P. has received grant for congress registration fee from GSK. L.P. has received a travel grant and a grant for congress registration fee from GSK. R.C. was the president of working group expert mandated by AFSSAPS until November 2011. The authors have no other funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Dr. François Angoulvant, Service d’Accueil des Urgences Pédiatriques, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019 Paris, France. E-mail: francois.angoulvant@rdb.aphp.fr.

© 2014 by Lippincott Williams & Wilkins, Inc.