Skip Navigation LinksHome > November 2013 - Volume 32 - Issue 11 > Varicella Zoster Virus Central Nervous System Immune Reconst...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31829aa4fc
Brief Reports

Varicella Zoster Virus Central Nervous System Immune Reconstitution Inflammatory Syndrome Presenting in a Child

Iro, Mildred A. MBBS, MRCPCH*; Kirkham, Fenella J. MA, MB, BChir, FRCPCH; Macdonald, Jason H. M. MBBS, MRCP, FRCR; Tebruegge, Marc DTM&H, DLSHTM, MRCPCH, MSc, MD§¶‖; Faust, Saul N. MA, MBBS, MRCPCH, PhD, FHEA§¶ **; Patel, Sanjay V. MA, MSc, MBBS, MRCPCH

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Abstract

A HIV-positive child presented with acute onset of right hemiplegia, facial palsy and dysphasia 4 weeks after commencing highly active antiretroviral therapy. Magnetic resonance imaging confirmed a left-sided cerebral infarct. Cerebrospinal fluid polymerase chain reaction was positive for varicella zoster virus. This is the first reported pediatric case of varicella zoster virus–related immune reconstitution inflammatory syndrome involving the central nervous system.

Copyright © 2013 by Lippincott Williams & Wilkins

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