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Prevalence of Vitamin D Deficiency Among Perinatally HIV-infected Thai Adolescents Receiving Antiretroviral Therapy

Chokephaibulkit, Kulkanya MD*; Saksawad, Rachanee MD*; Bunupuradah, Torsak MD; Rungmaitree, Supattra MD*; Phongsamart, Wanatpreeya MD*; Lapphra, Keswadee MD*; Maleesatharn, Alan MBA*; Puthanakit, Thanyawee MD†‡

The Pediatric Infectious Disease Journal: November 2013 - Volume 32 - Issue 11 - p 1237–1239
doi: 10.1097/INF.0b013e31829e7a5c
HIV Reports

We assessed the prevalence of vitamin D deficiency among 101 perinatally HIV-infected Thai adolescents receiving antiretroviral therapy. Median age was 14.3 (interquartile range 13.0–15.7) years, and 90% had a HIV RNA <50 copies/mL. The median (interquartile range) 25-hydroxyvitamin D (25-OHD) level was 24.8 (6.9–46.9) ng/mL; 25 (24.7%) had vitamin D deficiency (25-OHD <20 ng/mL) and 47 (46.5%) had insufficiency (25-OHD 20–30 ng/mL). Adolescents with vitamin D deficiency had significantly higher parathyroid hormone levels (54.9 vs. 40.2 pg/mL, P < 0.007). No associations between vitamin D deficiency and body mass index, bone mineral density, efavirenz use, HIV RNA, CD4 or self-reported sunlight exposure were observed.

From the *Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University; HIV-NAT/Thai Red Cross AIDS Research Centre; and Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Accepted for publication May 29, 2013.

Results from this study were presented in part at the 9th International Congress of Tropical Pediatrics, Bangkok, Thailand, October 18–20, 2011.

Funding support was provided through a grant to amfAR, The Foundation for AIDS Research, as part of the International Epidemiologic Databases to Evaluate AIDS (U01AI069907), by the U.S. National Institutes of Health: National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute Of Child Health & Human Development and National Cancer Institute, with additional funding from the AIDS Life Association. T.P. is funded in part by the National Research University Project of Commission of Higher Education and the Ratchadapiseksomphot Endowment Fund (HR 1161A-55) and the Senior Researcher Scholar, Thai Research Fund. The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of any of the institutions mentioned above. The authors have no other funding or conflicts of interest to disclose.

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Address for correspondence: Thanyawee Puthanakit, MD, Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330. E-mail: thanyawee.p@hivnat.org.

© 2013 by Lippincott Williams & Wilkins, Inc.