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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31829be0b0
Original Studies

Vitamin D Supplementation Reduces the Risk of Acute Otitis Media in Otitis-prone Children

Marchisio, Paola MD*; Consonni, Dario MD; Baggi, Elena MD*; Zampiero, Alberto PhD*; Bianchini, Sonia MD*; Terranova, Leonardo BSc*; Tirelli, Silvia PhD; Esposito, Susanna MD*; Principi, Nicola MD*

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Abstract

Background: The aim of this study was to evaluate whether a deficit in vitamin D (VD) is associated with an increased risk of recurrent acute otitis media (AOM) and whether VD supplementation is effective in reducing the number of AOM episodes in otitis-prone children.

Methods: A total of 116 children with a history of recurrent AOM (≥3 episodes in preceding 6 months or ≥4 episodes in preceding 12 months) were prospectively and blindly randomized to receive oral VD 1000 IU/d or placebo for 4 months. Episodes of AOM were monitored for 6 months.

Results: Fifty-eight children received placebo and 58 with similar characteristics were treated with VD. The number of children experiencing ≥1 AOM episode during the study period was significantly lower in the treatment group (26 versus 38; P = 0.03). There was a marked difference in the number of children who developed uncomplicated AOM (P < 0.001), but no difference in the number of children with ≥1 episode of spontaneous otorrhea. The likelihood of AOM was significantly reduced in the patients whose serum VD concentrations were ≥30 ng/mL.

Conclusions: VD hypovitaminosis is common in children with recurrent AOM and associated with an increase in the occurrence of AOM when serum 25(OH)D levels are <30 ng/mL. The administration of VD in a dosage of 1000 IU/d restores serum values of ≥30 ng/mL in most cases and is associated with a significant reduction in the risk of uncomplicated AOM.

© 2013 by Lippincott Williams & Wilkins, Inc.

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