Skip Navigation LinksHome > October 2013 - Volume 32 - Issue 10 > Tenofovir-induced Renal Tubular Dysfunction in Vertically HI...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31829e6c9c
HIV Reports

Tenofovir-induced Renal Tubular Dysfunction in Vertically HIV-infected Patients Associated With Polymorphisms in ABCC2, ABCC4 and ABCC10 Genes

Giacomet, Vania MD*; Cattaneo, Dario PhD†‡; Viganò, Alessandra MD*; Nannini, Pilar MD*; Manfredini, Valeria MD*; Ramponi, Giulia MD*; Clementi, Emilio MD†‡§; Zuccotti, Gian Vincenzo MD*

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Abstract

Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.

Copyright © 2013 by Lippincott Williams & Wilkins

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