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Gomila, Andres MD; Kirk, Brianna MD; Marape, Marape MBBCh, BAO, MPH, PhD; Anabwani, Gabriel MD, MSc; Tolle, Michael MD, MPH
With increasing use of protease inhibitors (PI) in Botswana, a large proportion of HIV-infected children are now exposed to PI-based regimens. There is limited protease genotype data from African children and adolescents who have failed PI-based antiretroviral therapy. We describe a cohort of pediatric HIV-infected patients experiencing virologic failure at time of second-line or salvage PI-based regimens and analyze associated PI mutations.
© 2013 by Lippincott Williams & Wilkins, Inc.
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HIV-1 subtype C, pediatric antiretroviral therapy, protease genotypes, protease resistance mutations, Botswana
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