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Oseltamivir Treatment for Influenza in Hospitalized Children Without Underlying Diseases

Bueno, Mercedes MD*; Calvo, Cristina MD, PhD; Méndez-Echevarría, Ana MD, PhD; de José, María Isabel MD, PhD; Santos, Mar MD§; Carrasco, Jaime MD; Tovizi, Miriann MD; Guillén, Sara MD**; de Blas, Ana MD††; Llorente, Marta MD‡‡; Tarrago, Alfredo MD§§; Escosa, Luis MD; Cilleruelo, María José MD, PhD; Tomatis, Cristina MD§; Blazquez, Daniel MD; Otheo, Enrique MD††; Mazagatos, Diana MD*; García-García, Maria Luz MD, PhD

Pediatric Infectious Disease Journal: October 2013 - Volume 32 - Issue 10 - p 1066–1069
doi: 10.1097/INF.0b013e31829be4bc
Original Studies

Aim: To determine whether the treatment with oseltamivir improves the outcome of children with confirmed influenza infection and no other underlying disease.

Methods: Multicentric, retrospective study performed in 10 hospitals of Madrid between September 2010 and June 2012. All children admitted to the hospitals with confirmed influenza infections were eligible. Children with risk factors for serious disease and nosocomial influenza infections were excluded. Asthma was not considered an exclusion factor. The study compared patients treated and untreated with oseltamivir. Fever duration, oxygen support, antibiotics administration, length of hospital stay, intensive care admission and bacterial complications were analyzed. To compare variables, χ2 test, Fisher exact test, ANOVA or Mann-Whitney U test were used.

Results: Two hundred eighty-seven children were included and 93 of them were treated with oseltamivir (32%). There were no significant differences between treated and untreated patients in days of fever after admission (1.7 ± 2; 2.1 ± 2.9, P > 0.05), length of stay (5.2 ± 3.6; 5.5 ± 3.4, P > 0.05), days of hypoxia (1.6 ± 2.3; 2.1 ± 2.9, P > 0.05), diagnosis of bacterial pneumonia (10%; 17%, P > 0.05), intensive care admission (6.5%; 1.5%,P > 0.05) or antibiotic prescription (44%; 51%, P > 0.05). There were no differences when the population was stratified by age (below or over 1 year) or by the presence or absence of asthma.

Conclusions: There were no proven benefits of treatment with oseltamivir in hospitalized pediatric patients without the underlying diseases or risk factors for developing a serious illness, including those with asthma.

From the *Fundación Hospital Alcorcón, Severo Ochoa Hospital, Hospital Infantil La Paz, §Hospital Gregorio Marañón, Hospital Puerta de Hierro, Hospital 12 de Octubre, **Hospital de Getafe, ††Hospital Ramón y Cajal, ‡‡Hospital del Sureste and §§Hospital Infanta Sofía, Madrid, Spain.

Accepted for publication May 14, 2013.

The authors have no funding or conflicts of interest to disclose.

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Address for correspondence: Cristina Calvo, C/Viento, 5, 5° A. 28760, Severo Ochoa Hospital, Avenida Orellana, sn, Leganés, Madrid, Spain. E-mail:ccalvorey@ono.com.

© 2013 by Lippincott Williams & Wilkins, Inc.