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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318299f75c
Antimicrobial Reviews

Desired Vancomycin Trough Serum Concentration for Treating Invasive Methicillin-resistant Staphylococcal Infections

Frymoyer, Adam MD*; Guglielmo, B. Joseph PharmD; Hersh, Adam L. MD, PhD

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Abstract

Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7–10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.

Copyright © 2013 by Lippincott Williams & Wilkins

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