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Clostridium difficile Infection in the Hospitalized Pediatric Population: Increasing Trend in Disease Incidence

Deshpande, Abhishek MD, PhD*; Pant, Chaitanya MD; Anderson, Michael P. PhD; Donskey, Curtis J. MD*‡; Sferra, Thomas J. MD§

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182948518
Brief Reports

To determine whether the incidence of Clostridium difficile infection continues to increase in hospitalized pediatric patients, we evaluated data from a United States national inpatient database. For the period of 2003 to 2009, we found an increasing trend in the incidence of C. difficile infection. These data suggest greater effort be given to prevent and treat this infection in children.

Author Information

From the *Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH; Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Research Service, Cleveland Veterans Affairs Medical Center; and §Department of Pediatrics, Case Western Reserve University School of Medicine, UH Rainbow Babies & Children’s Hospital, Cleveland, OH.

Accepted for publication March 28, 2013.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Thomas J. Sferra, MD, Martin and Betty Rosskamm Chair in Pediatric Gastroenterology, Chief, Pediatric Gastroenterology & Nutrition, UH Rainbow Babies & Children’s Hospital, 11100 Euclid Avenue, Suite 737, Cleveland, OH 44106. E-mail:

© 2013 by Lippincott Williams & Wilkins, Inc.