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Use of Nucleoside Reverse Transcriptase Inhibitor–only Regimens in HIV-infected Children and Adolescents

Neely, Michael MD, MSc, FCP*; Rutstein, Richard MD; Del Bianco, Gabriela MD; Heresi, Gloria MD; Barton, Theresa MD§; Wiznia, Andrew MD; Wiegand, Ryan MS; Wheeling, Travis MPH**; Bohannon, Beverly MS; Dominguez, Kenneth RNfor the LEGACY Consortium

The Pediatric Infectious Disease Journal: September 2013 - Volume 32 - Issue 9 - p e370–e376
doi: 10.1097/INF.0b013e31828e8c09
HIV Reports

Objective: In adults, nucleoside reverse transcriptase inhibitor–only antiretroviral regimens (NOARs) with ≥3 nucleoside reverse transcriptase inhibitors are less potent than highly active antiretroviral therapy (HAART). Published pediatric experience with NOARs is limited; thus, we wished to better define the virological, immunological and toxicological effects of NOARs in children and adolescents.

Methods: We analyzed data from NOAR-treated participants in LEGACY, a multicenter observational cohort study of HIV-infected children and adolescents. NOAR-treated case-participants were matched to participants without prior NOAR who initiated HAART during the same year for comparison.

Results: Of 575 participants with data from time of HIV diagnosis through 2006, 67 (12%) received NOARs for at least 24 weeks; most (46%) received the fixed dose combination of zidovudine/lamivudine/abacavir. NOAR use peaked in 2001 to 2002. NOAR-treated participants were significantly older and more treatment experienced than HAART-treated participants. Virologic outcomes, including the percentage of participants with a plasma HIV RNA viral load <400 copies/mL at week 24 (47% versus 34%) and the mean 24-week change in log10 plasma HIV RNA viral load from baseline (−0.63 versus −1.02), were similar between NOAR- and HAART-treated participants, but virologic rebound was more likely in NOAR-treated participants (77% versus 54%, P = 0.02). Increase in CD4 percentage points from baseline to 24 weeks was negligible in NOAR-treated participants compared with HAART-treated participants (0.95% versus 10.1%, P < 0.001). Anemia and leukopenia were more commonly reported with NOARs than HAART.

Discussion: Week 24 virologic outcomes were similar between NOAR- and HAART-treated participants, but NOAR durability was poorer and their use was associated with less immunologic reconstitution. NOARs should play a limited role in pediatric and adolescent antiretroviral therapy.

From the *Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA; Children’s Hospital of Philadelphia, Philadelphia, PA; University Texas Health Science Center at Houston, Houston, TX; §University Texas-Southwestern Medical Center, Dallas, TX; Jacobi Medical Center, Bronx, NY; Centers for Disease Control and Prevention; and **Northrop Grumman, Atlanta, GA.

Accepted for publication February 21, 2013.

M.N. was supported in part by NIH-NIAID 1 K23 AI076106, GM068968 and HD070886. The authors have no other funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Michael Neely, MD, MSc, FCP, Laboratory of Applied Pharmacokinetics, 2250 Alcazar St. CSC 134B, Los Angeles, CA 90033. E-mail: mneely@usc.edu.

© 2013 by Lippincott Williams & Wilkins, Inc.