Skip Navigation LinksHome > September 2013 - Volume 32 - Issue 9 > Optimization of Continuous Infusion of Piperacillin–Tazobact...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318298dfb8
Antimicrobial Reviews

Optimization of Continuous Infusion of Piperacillin–Tazobactam in Children With Fever and Neutropenia

Delvallée, Mélanie MD*†; Mazingue, Françoise MD†‡; Abouchahla, Wadi MD†‡; Delebarre, Mathilde MD†‡; Wallet, Frédéric MD*†; Courcol, René MD, PhD*†; Kipnis, Eric MD, PhD†§¶; Dessein, Rodrigue MD, PhD*†¶

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Abstract

The study through Monte Carlo simulation of β-lactam pharmacokinetic/pharmacodynamic target attainment and determination of subsequent serum concentrations of piperacillin–tazobactam administered through continuous infusion to children treated for fever and neutropenia shows that 400 mg/kg/day has the highest probability of target attainment against Pseudomonas aeurginosa in our oncology ward compared with the standard regimen of 300 mg/kg/day.

Copyright © 2013 by Lippincott Williams & Wilkins

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