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Implementation of Occult Hepatitis Screening in the Spanish Cohort of HIV-infected Pediatric Patients

Dapena, Marta MD*; Figueras, Concepción MD, PhD*; Noguera-Julian, Antoni MD, PhD; Fortuny, Clàudia MD, PhD; de José, María Isabel MD, PhD; Mellado, María José MD, PhD§; Gavilán, César MD; Falcón-Neyra, María Dolores MD; Navarro, María Luisa MD, PhD**; de Ory, Santiago Jiménez MSc††; López, Carmen MD‡‡; Mayol, Lluis MD, PhD§§; Méndez, María MD¶¶; Ciria, Luis Miguel MD‖‖; Coll, María Teresa MD***; García, Lourdes MD†††; Nuñez, Esmeralda MD‡‡‡; Espiau, María MD*; Soler-Palacín, Pere MD, PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31828e9b99
HIV Reports
Abstract

Regular screening methods may miss the diagnosis of occult hepatitis B infection and seronegative hepatitis C virus infection in immunocompromised patients. A cross-sectional study within a Spanish cohort of HIV-infected children yielded 6 of 254 (2.4%) possible occult hepatitis B infection cases and 2 of 254 (0.8%) seronegative hepatitis C virus–infected patients. Implementation of occult hepatitis screening in the routine care of these children may be warranted.

Author Information

From the *Hospital Universitari Vall d’Hebron, Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona; Department of Pediatrics, Hospital Sant Joan de Déu, Infectious Diseases Unit, Universitat de Barcelona, Barcelona; Department of Pediatrics, Hospital Universitario La Paz, Infectious Diseases Unit; §Department of Pediatrics, Hospital Universitario Carlos III, Infectious Diseases Unit, Madrid; Department of Pediatrics, Hospital San Joan d’Alacant, Infectious Diseases Unit, Alacant; Department of Pediatrics, Hospital Virgen del Rocío, Infectious Diseases Unit, Sevilla; **Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Infectious Diseases Unit; ††Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid; ‡‡Department of Pediatrics, Hospital General de Castelló, Infectious Diseases Unit, Castelló; §§Department of Pediatrics, Hospital Josep Trueta, Infectious Diseases Unit, Girona; ¶¶Department of Pediatrics, Hospital Germans Trias i Pujol, Infectious Diseases Unit, Badalona, Barcelona; ‖‖Department of Pediatrics, Hospital Infantil Universitario Miguel Servet, Infectious Diseases Unit, Zaragoza; ***Department of Pediatrics, Hospital Asil de Granollers, Infectious Diseases Unit, Granollers; †††Department of Pediatrics, Hospital de Mataró, Infectius Diseases Unit, Mataró, Barcelona; and ‡‡‡Department of Pediatrics, Hospital Carlos Haya, Infectious Diseases Unit, Málaga, Spain.

Accepted for publication 21, 2013.

This study was supported by Red de Investigación en Sida (RIS) RD06/0006 from ISCIII. S.J.d.O. received financial support from Red Temática de Investigación Cooperativa Sanitaria ISCIII (RED RIS RD06/0006/0035 and RD06/0006/0021) and FIPSE (36910/10). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Pere Soler-Palacín, MD, PhD, Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig de la Vall d’Hebron, 119–129, 08035, Barcelona, Spain. E-mail: psoler@vhebron.net.

© 2013 by Lippincott Williams & Wilkins, Inc.