You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Implementation of Occult Hepatitis Screening in the Spanish Cohort of HIV-infected Pediatric Patients

Dapena, Marta MD*; Figueras, Concepción MD, PhD*; Noguera-Julian, Antoni MD, PhD; Fortuny, Clàudia MD, PhD; de José, María Isabel MD, PhD; Mellado, María José MD, PhD§; Gavilán, César MD; Falcón-Neyra, María Dolores MD; Navarro, María Luisa MD, PhD**; de Ory, Santiago Jiménez MSc††; López, Carmen MD‡‡; Mayol, Lluis MD, PhD§§; Méndez, María MD¶¶; Ciria, Luis Miguel MD‖‖; Coll, María Teresa MD***; García, Lourdes MD†††; Nuñez, Esmeralda MD‡‡‡; Espiau, María MD*; Soler-Palacín, Pere MD, PhD*

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31828e9b99
HIV Reports

Regular screening methods may miss the diagnosis of occult hepatitis B infection and seronegative hepatitis C virus infection in immunocompromised patients. A cross-sectional study within a Spanish cohort of HIV-infected children yielded 6 of 254 (2.4%) possible occult hepatitis B infection cases and 2 of 254 (0.8%) seronegative hepatitis C virus–infected patients. Implementation of occult hepatitis screening in the routine care of these children may be warranted.

Author Information

From the *Hospital Universitari Vall d’Hebron, Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona; Department of Pediatrics, Hospital Sant Joan de Déu, Infectious Diseases Unit, Universitat de Barcelona, Barcelona; Department of Pediatrics, Hospital Universitario La Paz, Infectious Diseases Unit; §Department of Pediatrics, Hospital Universitario Carlos III, Infectious Diseases Unit, Madrid; Department of Pediatrics, Hospital San Joan d’Alacant, Infectious Diseases Unit, Alacant; Department of Pediatrics, Hospital Virgen del Rocío, Infectious Diseases Unit, Sevilla; **Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Infectious Diseases Unit; ††Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid; ‡‡Department of Pediatrics, Hospital General de Castelló, Infectious Diseases Unit, Castelló; §§Department of Pediatrics, Hospital Josep Trueta, Infectious Diseases Unit, Girona; ¶¶Department of Pediatrics, Hospital Germans Trias i Pujol, Infectious Diseases Unit, Badalona, Barcelona; ‖‖Department of Pediatrics, Hospital Infantil Universitario Miguel Servet, Infectious Diseases Unit, Zaragoza; ***Department of Pediatrics, Hospital Asil de Granollers, Infectious Diseases Unit, Granollers; †††Department of Pediatrics, Hospital de Mataró, Infectius Diseases Unit, Mataró, Barcelona; and ‡‡‡Department of Pediatrics, Hospital Carlos Haya, Infectious Diseases Unit, Málaga, Spain.

Accepted for publication 21, 2013.

This study was supported by Red de Investigación en Sida (RIS) RD06/0006 from ISCIII. S.J.d.O. received financial support from Red Temática de Investigación Cooperativa Sanitaria ISCIII (RED RIS RD06/0006/0035 and RD06/0006/0021) and FIPSE (36910/10). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Pere Soler-Palacín, MD, PhD, Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Passeig de la Vall d’Hebron, 119–129, 08035, Barcelona, Spain. E-mail:

© 2013 by Lippincott Williams & Wilkins, Inc.