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Insulin Resistance and Glucose and Lipid Concentrations in a Cohort of Perinatally HIV-infected Latin American Children

Hazra, Rohan MD*; Hance, Laura Freimanis PhD, MD; Monteiro, Jacqueline Pontes PhD; Ruz, Noris Pavia MD, MsC§; Machado, Daisy Maria MD, PhD; Saavedra, Mariza MD; Motta, Fabrizio MS**; Harris, D. Robert PhD; for the NISDI Pediatric Study Group 2012

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318286c774
HIV Reports
Abstract

We measured glucose, insulin and lipids in 249 perinatally HIV-infected Latin American children. Only 1 subject had impaired fasting glucose; 6.8% had insulin resistance. Abnormalities in total, low-density lipoprotein and high-density lipoprotein cholesterol and triglycerides were reported for 13%, 13%, 21% and 34%, respectively. Continued follow-up of this population is necessary to characterize the evolution and clinical consequences of these findings.

Author Information

From the *Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD; Westat, Rockville, MD; University of São Paulo, Ribeirão Preto, SP, Brazil; §Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico; Federal University of São Paulo, São Paulo; Hospital Federal dos Servidores do Estado, Rio de Janeiro; and **Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil.

Supported by NICHD Contract # HHSN267200800001C (NICHD Control # N01-HD-8-0001). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Rohan Hazra, MD, Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Room 4B11, Bethesda, MD 20892–7510. E-mail: hazrar@mail.nih.gov.

© 2013 by Lippincott Williams & Wilkins, Inc.