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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182829092
HIV Reports

Resistance in Pediatric Patients Experiencing Virologic Failure With First-line and Second-line Antiretroviral Therapy

Orrell, Catherine MB ChB*; Levison, Julie MD†‡§¶; Ciaranello, Andrea MD, MPH†‡§; Bekker, Linda-Gail PhD*; Kuritzkes, Daniel R. MD‡¶; Freedberg, Kenneth A. MD, MSc†‡§¶‖**; Wood, Robin FRCP*

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Abstract

We examined HIV-1 resistance in children failing first-line and second-line antiretroviral therapy in South Africa, all with clade C virus. Those exposed to full-dose ritonavir had multiple protease resistance mutations. Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options.

© 2013 Lippincott Williams & Wilkins, Inc.

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