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Incidence and Characteristics of Sporadic Norovirus Gastroenteritis Associated with Hospitalization of Children Less Than 5 Years of Age in Israel

Muhsen, Khitam PhD*†; Kassem, Eias MD; Rubinstein, Uri MD§; Schachter, Yaakov MD§; Kremer, Adi MD; Goren, Sophy BSc*; Zilberstein, Ilana MSc; Ephros, Moshe MD‖ **; Cohen, Dani PhD*; Shulman, Lester M. PhD

Pediatric Infectious Disease Journal: June 2013 - Volume 32 - Issue 6 - p 688–690
doi: 10.1097/INF.0b013e318287fc81
Brief Reports

The incidence of sporadic GII norovirus gastroenteritis associated with hospitalization was examined among 515 children aged <5 years in a prospective study in Israel. Using real-time polymerase chain reaction, norovirus was detected in stools of 89 (17.3%) children, yielding an estimated incidence of 3.3 per 1000 children. Genotypes GII.3 (40.4%) and GII.4a (21.3%) predominated, though year-to-year variation was observed.

From the *Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medicine, Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD; Departments of Pediatrics Hillel Yaffe Medical Center, Hadera; §Departments of Pediatrics Laniado Medical Center, Natanya; Medical Central Virology Laboratory, Ministry of Health, Tel Hashomer; Pediatric Infectious Disease Unit, Carmel Medical Center, Haifa; **Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

The first year of the study was supported by the Department of Immunization, Vaccination and Biologicals, World Health Organization (V27-181-190).

The authors have no other funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: Khitam Muhsen, PhD, Center for Vaccine Development, University of Maryland, School of Medicine, 685 West Baltimore Street, HSF-II room 480, Baltimore, MD 21201. E-mail: kmuhsen@medicine.umaryland.edu, khitam15@yahoo.com.

© 2013 Lippincott Williams & Wilkins, Inc.