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Evaluation of IgG Anti-Toxoplasma Avidity and Polymerase Chain Reaction in the Postnatal Diagnosis of Congenital Toxoplasmosis

Torres, Elizabeth MSc; Rivera, Raul MSc; Cardona, Nestor MSc; Sanchez, Victor BSc; Lora, Fabiana MSc; Gómez-Marín, Jorge Enrique MD, PhD

The Pediatric Infectious Disease Journal: June 2013 - Volume 32 - Issue 6 - p 693–695
doi: 10.1097/INF.0b013e31828807a4
Brief Reports

Confirmatory tests for congenital toxoplasmosis were evaluated in 23 infected and 31 uninfected newborns. Conventional polymerase chain reaction was better than real-time polymerase chain reaction, but did not identify additional cases. Avidity tests added 2 new cases that were not identified by other criteria. Overall sensitivity was 82.6%. Avidity assay, but not polymerase chain reaction, increased the sensitivity of confirmatory assays in congenital toxoplasmosis.

From the Grupo de Estudio en Parasitología Molecular, Centro de Investigaciones Biomédicas, Universidad del Quindio, Armenia (Q), Colombia.

This work was financed by a grant from Colciencias (Grant number 1113-04-18247), a Colombian scientific governmental agency. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Jorge Enrique Gómez-Marín, MD, PhD, Centro de Investigaciones Biomedicas, Universidad del Quindio, Av Bolivar 12N, Armenia, Colombia. E-mail:

© 2013 Lippincott Williams & Wilkins, Inc.