Home Current Issue Previous Issues Published Ahead-of-Print Collections For Authors Journal Info
Skip Navigation LinksHome > May 2013 - Volume 32 - Issue 5 > Polymicrobial Acute Respiratory Infections in a Hospital-bas...
Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31828683ce
Original Studies

Polymicrobial Acute Respiratory Infections in a Hospital-based Pediatric Population

Chorazy, Margaret L. PhD, MPH*; Lebeck, Mark G. MS; McCarthy, Troy A. BA; Richter, Sandra S. MD§; Torner, James C. PhD, MS*; Gray, Gregory C. MD, MPH

Supplemental Author Material
Collapse Box

Abstract

Background: The clinical impact of polymicrobial respiratory infections remains uncertain. Previous reports are contradictory regarding an association with severe disease.

Methods: Three hundred forty-six specimens from children with acute respiratory illness identified at the University of Iowa Hospitals and Clinics Clinical Microbiology Laboratory were evaluated by direct immunofluorescent assay and/or viral culture by Clinical Microbiology Laboratory and later by molecular study for the presence of influenza, parainfluenza, respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus and human bocavirus. Demographic and clinical data were abstracted from medical records.

Results: Multiple viruses were detected in 46 (21.7%) of 212 virus-positive specimens with the most frequent virus–virus combinations being HRV-respiratory syncytial virus (n = 12), HRV-human bocavirus (n = 6) and HRV-parainfluenza virus 3 (n = 4). Risk factors for coinfection included male gender (OR [odds ratio]: 1.70, 95% confidence interval [CI]: 0.83–3.46), 6 months to 1 year age (OR: 2.15, 95% CI: 0.75–6.19) and history of immunosuppression (OR: 2.05, 95% CI: 0.99–4.23). Children with viral coinfections were less likely than children with single virus infections to be admitted to an intensive care unit (OR: 0.32, 95% CI: 0.08–1.27); however, this may be explained by undetected viral–bacterial coinfections.

Conclusions: HRV, respiratory syncytial virus, human bocavirus, and polymicrobial infections were prevalent in this study. Although the cross-sectional design could not easily examine polymicrobial infection and disease severity, prospective, population-based research regarding the clinical impact of such infections is warranted.

© 2013 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.