Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger.
From the *Paediatric HIV Diagnostic Syndicate, Wits Health Consortium; †Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Parktown; and ‡National Health and Laboratory Service, Johannesburg, South Africa.
Accepted for publication October 26, 2012.
USAID/PEPFAR, Bristol Myers-Squibb Secure The Future, and UNICEF funded various stages of this study. The authors have no other funding or conflicts of interest to disclose.
Address for correspondence: Kapila Bhowan, ND, Biomed Tech, BTech, PO Box 1474, Glenvista, 2058, Johannesburg, South Africa. E-mail: firstname.lastname@example.org.