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Performance of the First Fourth-generation Rapid Human Immunodeficiency Virus Test in Children

Bhowan, Kapila ND*; Sherman, Gayle G. MD, PhD*†‡

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31827b4775
HIV Reports
Abstract

Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger.

Author Information

From the *Paediatric HIV Diagnostic Syndicate, Wits Health Consortium; Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Parktown; and National Health and Laboratory Service, Johannesburg, South Africa.

Accepted for publication October 26, 2012.

USAID/PEPFAR, Bristol Myers-Squibb Secure The Future, and UNICEF funded various stages of this study. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Kapila Bhowan, ND, Biomed Tech, BTech, PO Box 1474, Glenvista, 2058, Johannesburg, South Africa. E-mail: kbhowan@gmail.com.

© 2013 Lippincott Williams & Wilkins, Inc.