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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31827b4775
HIV Reports

Performance of the First Fourth-generation Rapid Human Immunodeficiency Virus Test in Children

Bhowan, Kapila ND*; Sherman, Gayle G. MD, PhD*†‡

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Abstract

Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger.

© 2013 Lippincott Williams & Wilkins, Inc.

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