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Hospital-Based Surveillance for Rotavirus Gastroenteritis using Molecular Testing and Immunoassay During the 2011 Season in Botswana

Welch, Henry MD*†; Steenhoff, Andrew P. MD*†‡; Chakalisa, Unoda MD*; Arscott-Mills, Tonya MD*†‡; Mazhani, Loeto MD‡§; Mokomane, Margaret MSc; Foster-Fabiano, Sara BA; Wirth, Kathleen E. ScD**; Skinn, Andrew MD, PhD††; Pernica, Jeffrey M. MD‡‡; Smieja, Marek MD‡‡; Goldfarb, David M. MD*‡‡‡

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182847295
Brief Reports
Abstract

We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 rotavirus season. The rotavirus season extended from June to October with rotavirus-specific case fatality being 2.8%. Using molecular testing as reference, the immunochromatographic test had a sensitivity of 76.5% and specificity of 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity and mortality in Botswana.

Author Information

From the *Botswana-UPenn Partnership; Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Paediatrics and Adolescent Health, School of Medicine, University of Botswana; §Princess Marina Hospital; National Health Laboratory, Botswana Ministry of Health; Wake Forest School of Medicine, Winston-Salem, NC; **Department of Epidemiology, Harvard School of Public Health, Boston, MA and Botswana Harvard AIDS Institute, Gaborone, Botswana; ††University of Ottawa, Canada; and ‡‡McMaster University, Hamilton, Canada.

Accepted for publication December 21, 2012.

Funds for this project were received from Grand Challenges Canada and the Stokes Research Institute, Children’s Hospital of Philadelphia. This publication was made possible through core services and support from the Penn Center for AIDS Research, an NIH-funded program (P30 AI 045008). Dr. Wirth received support from National Institute of General Medical Sciences grant number U54GM088558. The authors have no other funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com).

Address for correspondence: David Goldfarb, MD, Assistant Professor, Department of Pediatrics, Division of Infectious Disease, McMaster Children’s Hospital, Rm 3A – 31, 1280 Main St. West, Hamilton, ON. E-mail:goldfar@mcmaster.ca.

© 2013 Lippincott Williams & Wilkins, Inc.