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Effectiveness of First-line Antiretroviral Therapy and Acquired Drug Resistance Among HIV-1infected Children in India

Shet, Anita MD*†; Neogi, Ujjwal MSc‡§; Sahoo, Pravat Nalini MSc; De Costa, Ayesha MD, PhD

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31827fb2d1
HIV Reports
Abstract

Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologic failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologic monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.

Author Information

From the *Department of Paediatrics, St. John’s Medical College and Hospital, Bangalore, India; Division of Global Health, Karolinska Institutet, Sweden; Department of Microbiology, Division of Clinical Virology, St. John’s Medical College and Hospital, Bangalore, India; and §Department of Medicine, Division of Infectious Disease, Huddinge, Karolinska Institutet, Sweden.

Accepted for publication November 27, 2012.

A.S. designed the study and worked with obtaining clinical data, data analysis and drafting the article. U.N. and P.N.S. worked with laboratory experimental design, data analysis and writing sections in the article. A.D.C. worked with study design, data analysis and critical review of the article. All authors have read and have approved the final draft. The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Anita Shet, MD, Department of Pediatrics, St John’s Medical College Hospital, Sarjapur Road, Bangalore 560034, India. E-mail: anitashet@gmail.com.

© 2013 Lippincott Williams & Wilkins, Inc.