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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e31827fb2d1
HIV Reports

Effectiveness of First-line Antiretroviral Therapy and Acquired Drug Resistance Among HIV-1–infected Children in India

Shet, Anita MD*†; Neogi, Ujjwal MSc‡§; Sahoo, Pravat Nalini MSc; De Costa, Ayesha MD, PhD

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Abstract

Analysis of treatment response among HIV-infected children in India on first-line antiretroviral treatment for >2 years revealed that 85% were virologically suppressed. Of those with virologic failure, only 17% manifested immunologic failure, whereas majority had resistance-associated mutations. The presence of resistance highlights the need for virologic monitoring of children receiving antiretroviral treatment to optimize treatment success and preserve future treatment options.

© 2013 Lippincott Williams & Wilkins, Inc.

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