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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e318279c800
HIV Reports

Antiretroviral Regimens Containing a Single Protease Inhibitor Increase Risk of Virologic Failure in Young HIV-infected Children

Walters, Elisabetta FCPaed, MMed*; Reichmuth, Kirsten MBChB; Dramowski, Angela FCPaed, MMed; Marais, Ben J. PhD§; Cotton, Mark F. FCPaed, PhD; Rabie, Helena FCPaed, MMed, MSc

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Abstract

Rifampin-based tuberculosis treatment can cause subtherapeutic concentrations of protease inhibitors and virologic failure in children receiving antiretroviral therapy. Among 217 children on antiretroviral therapy, tuberculosis cotreatment (in 78) was associated with virologic failure. Ritonavir-based single protease inhibitor antiretroviral therapy regimen predicted virologic failure (adjusted odds ratio 3.7, 95% confidence interval 1.5–8.9, P = 0.004) on multivariate analysis.

© 2013 Lippincott Williams & Wilkins, Inc.

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