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Prevalence of Human Leukocyte Antigen-B*5701 Among HIV-infected Children in Thailand and Cambodia: Implications for Abacavir Use

Puthanakit, Thanyawee MD*†; Bunupuradah, Torsak MD*; Kosalaraksa, Pope MD; Vibol, Ung MD§; Hansudewechakul, Rawiwan MD; Ubolyam, Sasiwimol MSc*; Suwanlerk, Tulathip BNS*; Kanjanavanit, Suparat MD; Ngampiyaskul, Chaiwat MD**; Wongsawat, Jurai MD††; Luesomboon, Wicharn MD‡‡; Vonthanak, Saphonn MD, PhD§§; Ananworanich, Jintanat MD, PhD*¶¶‖‖; Ruxrungtham, Kiat MD, MSc*‖‖

Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182745dba
HIV Reports
Abstract

Human leukocyte antigen (HLA)-B*5701 allele is associated with abacavir hypersensitivity. Limited data among Asians showed lower rates of HLA-B*5701 compared with Caucasians. In 296 children with HIV in Thailand and Cambodia, the prevalence of HLA-B*5701 was 4.0% (95% confidence interval: 1.6–8.0%) among Thai and 3.4% (95% confidence interval: 0.9–8.5%) among Cambodian children. HLA-B*5701 carriage is not uncommon among Thai and Cambodian children; it is close to the prevalence found in European and higher than the prevalence found in East Asian and African studies.

Author Information

From the *HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, The Thai Red Cross AIDS Research Center; Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok; Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand; §National Pediatric Hospital, Phnom Penh, Cambodia; Chiangrai Prachanukroh Hospital, Chiang Rai; Nakornping Hospital, Chiang Mai; **Prapokklao Hospital, Chantaburi; ††Bamrasnaradura Infectious Disease Institute, Nonthaburi; ‡‡Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand; §§National Center for HIV/AIDS, Dermatology and STDs (NCHADS), Phnom Penh, Cambodia; ¶¶SEARCH, The Thai Red Cross AIDS Research Center; and ‖‖Department of Medicine, Chulalongkorn University, Bangkok, Thailand.

Accepted for publication August 28, 2012.

The study was funded by the Commission of Higher Education, Bangkok, Thailand, TREAT Asia/amfAR, the Foundation for AIDS Research through the ViiV Healthcare Paediatric Innovation Seed Fund and the National Research University Project of Commission of Higher Education and the Ratchadapisek Somphot Endowment Fund (HR 1161A-55). TP is supported by the grants from the Senior Researcher Scholar, Thai Research Fund. KR is supported by the grants from the Senior Researcher Scholar, Thai Research Fund; and the Professional Research Team Strengthening Fund, BIOTEC, Bangkok, Thailand. JA and KR received consultation or speaker honoraria from ViiV Health Care (Middlesex, UK). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Thanyawee Puthanakit, MD, Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. E-mail: thanyawee.p@hivnat.org.

© 2013 Lippincott Williams & Wilkins, Inc.