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Pediatric Infectious Disease Journal:
doi: 10.1097/INF.0b013e3182787bff
Vaccine Reports

Three-year Antibody Persistence and Safety After a Single Dose of Combined Haemophilus influenzae Type b (Hib)–Neisseria meningitidis Serogroup C-tetanus Toxoid Conjugate Vaccine in Hib-primed Toddlers

Booy, Robert MB BS, MSc, MD*; Richmond, Peter MB BS; Nolan, Terry MB BS, PhD; McVernon, Jodie MB BS, PhD; Marshall, Helen MB BS, MPH§; Nissen, Michael MB BS; Reynolds, Graham MD; Ziegler, John B. MD**; Stoney, Tanya MB BS††; Heron, Leon MB ChB, MPH*; Lambert, Stephen MB BS, PhD; Mesaros, Narcisa MD‡‡; Peddiraju, Kavitha MSc§§; Miller, Jacqueline M. MD¶¶

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Background: Persistence of seroprotective bactericidal antibody titers is important for long-term protection against meningococcal serogroup C disease in young children. Antibody persistence values were determined in children up to 3 years after vaccination with a single dose of the combined Haemophilus influenzae type b (Hib)–Neisseria meningitidis serogroup C (MenC)-tetanus toxoid (TT) conjugate vaccine (Hib-MenC-TT; NCT00326118).

Methods: The children had been randomized at ages 12–18 months to receive either 1 dose of Hib-MenC-TT (Hib-MenC group) or separately administered Hib-TT conjugate vaccine and MenC-CRM197 (MCC) vaccine (Hib plus MCC group). All children had been primed in infancy with a Hib vaccine. Antibodies against MenC were measured by a serum bactericidal assay using rabbit complement (rSBA-MenC) and antibodies against Hib polyribosylribitol phosphate were assessed by enzyme-linked immunosorbent assay.

Results: The rSBA-MenC titers ≥1:8 were demonstrated 3 years after vaccination in 64.2% and 53.2% of participants in the Hib-MenC group and in the Hib plus MCC group, respectively. Antipolyribosylribitol phosphate concentrations ≥0.15 µg/mL persisted in >98% of participants in both groups. The rSBA–MenC geometric mean titers and antipolyribosylribitol phosphate geometric mean concentrations remained higher 3 years after vaccination than before vaccination. No serious adverse events assessed by the investigator as being related to vaccination were reported.

Conclusion: In this antibody persistence study of Hib-primed but MenC-naïve toddlers who received a single dose of Hib-MenC-TT, protective antibody levels against Hib and MenC were maintained in the majority of children 3 years after vaccination.

© 2013 Lippincott Williams & Wilkins, Inc.


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